To celebrate the 25th anniversary of the Wexner Center for the Arts, the multidisciplinary contemporary arts institution will hold its most impressive exhibition in “Transfigurations: Modern Masters from the Wexner Family Collection,” which opens to the public on Sept. 20. That this is the Wexner Center’s most significant exhibition is saying a lot, considering past ones have included icons like Andy Warhol and Annie Leibovitz.

When modern masters like Alberto Giacometti, Jean Dubuffet and Pablo Picasso are involved — all from the personal collection of Leslie and Abigail Wexner — it signals a watershed moment.