he era of the world-class museum built by a single philanthropist in the tradition of Isabella Stewart Gardner, John Pierpont Morgan Jr. and Gertrude Vanderbilt Whitney may seem to have passed, but Alice L. Walton is bringing it back.

Yet her mission is unlike those of her predecessors, or of more recent art patrons like Ronald S. Lauder and his Neue Galerie. They set out to put great works on display in cultural capitals like New York and Boston. Instead, Ms. Walton’s Crystal Bridges Museum of American Art — the first major institution dedicated to American artists in 50 years, to be housed in a building more than twice the size of the current Whitney Museum of American Art — seeks to bring high art to middle America here in this town of 35,000 that is best known as the home of Wal-Mart.

Ms. Walton, the daughter of Wal-Mart’s founder, Sam Walton, has worked on the museum for nearly a decade, but has said little about it in public until now. In a recent interview at Town Branch, her family home here, she said she wanted to turn Bentonville into an international destination for art lovers when the museum opens on Nov. 11. At the moment the most significant nearby cultural attractions are two hours away: a museum of Western and American Indian art in Tulsa, Okla., and, in the other direction, the country-music magnet of Branson, Mo.

“For years I’ve been thinking about what we could do as a family that could really make a difference in this part of the world,” said Ms. Walton, who is 61. “I thought this is something we desperately need, and what a difference it would have made were it here when I was growing up.”

The 201,000-square-foot museum was designed by the Boston architect Moshe Safdie for a site around two ponds on 120 acres of former Walton family land. Named for the nearby Crystal Spring, the museum will display top-flight works by American masters from the colonial era to the present, with the largest concentrations coming from the 19th and 20th centuries. Although the collection — currently about 600 paintings and sculptures — is still small by the standards of big museums, it is growing at a steady clip.

“She has not just been concentrating on what could be perceived as the greatest hits in American art,” said John Wilmerding, an art historian and professor at Princeton University, who has been advising Ms. Walton for seven years and is now on the Crystal Bridges board. “She has collected the work of some of these artists in depth,” quietly amassing substantial bodies of work by figures like Martin Johnson Heade, Stuart Davis, George Bellows and John Singer Sargent.